TFF-EVs-Small: Tangential Flow Filtration-based Device

Overview

The TFF-EVs-Small is a cutting-edge tangential flow filtration (TFF) device designed for efficient purification and concentration of extracellular vesicles (EVs). This innovative tool offers a rapid, reproducible, and scalable solution for EV isolation, making it an essential asset for researchers in the field of EV biology and biomarker discovery.

Key Features

• Sample Compatibility: EVs containing matrices (urine, conditioned cell media, plasma, serum)

• Quantity: 1 concentrator per package

• Filter Cartridge:

  • Material: Hollow fibers made of polyethersulfone

  • Filtering surface: 0.025 sqm

  • Fiber pore size: 50 ± 10 nm

  • Cut off: 800 kDa

• Sterilization: e-beam sterilization

• Sample Volume: 10 ml up to 1000 ml per reaction

• EV Recovery Rate: 81%

• Concentration Time: 5 minutes

• Reusability: Multiple times

Applications

• Fast and scalable EV purification and concentration

• Depletion of FBS from bovine EVs

• Particle buffer exchange and removal of unbound dye

Why Choose TFF-EVs-Small?

1. Efficiency: High EV recovery rate of 81%

2. Speed: Concentrate your samples in just 5 minutes

3. Versatility: Suitable for various sample types and volumes

4. Scalability: Can be used on the lab bench or connected to a mechanical system for larger volumes

5. Cost-effective: Reusable for multiple reactions

How It Works

Our TFF-EVs-Small utilizes tangential flow filtration, an emerging method recognized for its efficiency in EV purification. The sample flows parallel to the membrane surface, allowing for simultaneous concentration and purification of EVs.